Exploration of <i>N</i>-Arylsulfonyl-indole-2-carboxamide Derivatives as Novel Fructose-1,6-bisphosphatase Inhibitors by Molecular Simulation

Exploration of <i>N</i>-Arylsulfonyl-indole-2-carboxamide Derivatives as Novel Fructose-1,6-bisphosphatase Inhibitors by Molecular Simulation

A series of <i>N</i>-arylsulfonyl-indole-2-carboxamide derivatives have been identified as potent fructose-1,6-bisphosphatase (FBPase) inhibitors (FBPIs) with excellent selectivity for the potential therapy of type II diabetes mellitus. To explore the structure–activity relationships (SA...

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Bibliographic Details
Main Authors: Yilan Zhao, Honghao Yang, Fengshou Wu, Xiaogang Luo, Qi Sun, Weiliang Feng, Xiulian Ju, Genyan Liu
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
fructose-1,6-biphosphatase inhibitor
3D-QSAR
virtual screening
molecular docking
molecular dynamics
Online Access:https://www.mdpi.com/1422-0067/23/18/10259

Internet

https://www.mdpi.com/1422-0067/23/18/10259

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