Fc-engineered monoclonal antibodies to reduce off-target liver uptake

Fc-engineered monoclonal antibodies to reduce off-target liver uptake

Abstract Background Radiolabeled-antibodies usually display non-specific liver accumulation that may impair image analysis and antibody biodistribution. Here, we investigated whether Fc silencing influenced antibody biodistribution. We compared recombinant 89Zr-labeled antibodies (human IgG1 against...

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Bibliographic Details
Main Authors: Tristan Mangeat, Matthieu Gracia, Alexandre Pichard, Sophie Poty, Pierre Martineau, Bruno Robert, Emmanuel Deshayes
Format: Article
Language:English
Published: SpringerOpen 2023-09-01
Series:EJNMMI Research
Subjects:
PET-CT
Fc gamma receptor
Off-target
Fc
LALAPG mutation
Online Access:https://doi.org/10.1186/s13550-023-01030-0

Internet

https://doi.org/10.1186/s13550-023-01030-0

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