Sonic hedgehog-heat shock protein 90β axis promotes the development of nonalcoholic steatohepatitis in mice

Sonic hedgehog-heat shock protein 90β axis promotes the development of nonalcoholic steatohepatitis in mice

Abstract Sonic hedgehog (SHH) and heat shock protein 90β (HSP90β) have been implicated in nonalcoholic steatohepatitis (NASH) but their molecular mechanisms of action remain elusive. We find that HSP90β is a key SHH downstream molecule for promoting NASH process. In hepatocytes, SHH reduces HSP90β u...

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Bibliographic Details
Main Authors: Weitao Zhang, Junfeng Lu, Lianshun Feng, Hanyue Xue, Shiyang Shen, Shuiqing Lai, PingPing Li, Ping Li, Jian Kuang, Zhiwei Yang, Xiaojun Xu
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45520-8

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https://doi.org/10.1038/s41467-024-45520-8

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