A masked, placebo-controlled, randomized clinical trial evaluating safety and the effect on cardiac function of low-dose rapamycin in 17 healthy client-owned dogs

A masked, placebo-controlled, randomized clinical trial evaluating safety and the effect on cardiac function of low-dose rapamycin in 17 healthy client-owned dogs

Introduction:Geroscience studies of low-dose rapamycin in laboratory species have identified numerous benefits, including reversing age-related cardiac dysfunction. Cardiovascular benefits have been observed in dogs with 10 weeks of treatment, raising questions about possible benefits and adverse ef...

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Bibliographic Details
Main Authors: Brian G. Barnett, Sonya R. Wesselowski, Sonya G. Gordon, Ashley B. Saunders, Daniel E. L. Promislow, Stephen M. Schwartz, Lucy Chou, Jeremy B. Evans, Matt Kaeberlein, Kate E. Creevy
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Veterinary Science
Subjects:
diastolic function
aging
age-related decline
echocardiography
geroscience
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2023.1168711/full

Internet

https://www.frontiersin.org/articles/10.3389/fvets.2023.1168711/full

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