Substantiate a read-across hypothesis by using transcriptome data—A case study on volatile diketones

Substantiate a read-across hypothesis by using transcriptome data—A case study on volatile diketones

This case study explores the applicability of transcriptome data to characterize a common mechanism of action within groups of short-chain aliphatic α-, β-, and γ-diketones. Human reference in vivo data indicate that the α-diketone diacetyl induces bronchiolitis obliterans in workers involved in the...

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Bibliographic Details
Main Authors: Christina Drake, Matthias M. Wehr, Walter Zobl, Jeannette Koschmann, David De Lucca, Britta A. Kühne, Tanja Hansen, Jan Knebel, Detlef Ritter, Jan Boei, Harry Vrieling, Annette Bitsch, Sylvia E. Escher
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Toxicology
Subjects:
read across
new approach methodology
transcriptomics
TempO-seq
PBEC
protein network analysis
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2023.1155645/full

Internet

https://www.frontiersin.org/articles/10.3389/ftox.2023.1155645/full

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