Substantiate a read-across hypothesis by using transcriptome data—A case study on volatile diketones
This case study explores the applicability of transcriptome data to characterize a common mechanism of action within groups of short-chain aliphatic α-, β-, and γ-diketones. Human reference in vivo data indicate that the α-diketone diacetyl induces bronchiolitis obliterans in workers involved in the...
Main Authors: | Christina Drake, Matthias M. Wehr, Walter Zobl, Jeannette Koschmann, David De Lucca, Britta A. Kühne, Tanja Hansen, Jan Knebel, Detlef Ritter, Jan Boei, Harry Vrieling, Annette Bitsch, Sylvia E. Escher |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-05-01
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Series: | Frontiers in Toxicology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/ftox.2023.1155645/full |
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