Long-Acting Paliperidone Parenteral Formulations Based on Polycaprolactone Nanoparticles; the Influence of Stabilizer and Chitosan on In Vitro Release, Protein Adsorption, and Cytotoxicity

Long-Acting Paliperidone Parenteral Formulations Based on Polycaprolactone Nanoparticles; the Influence of Stabilizer and Chitosan on In Vitro Release, Protein Adsorption, and Cytotoxicity

Long-acting preparations containing the antipsychotic paliperidone for intramuscular injection has drawn considerable attention to achieve harmless long-term treatment. This study aimed to develop paliperidone loaded polycaprolactone (PCL) nanoparticles and investigate the influence of PCL/drug rati...

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Bibliographic Details
Main Authors: Mohammed Elmowafy, Nabil K. Alruwaili, Khaled Shalaby, Khalid S. Alharbi, Waleed M. Altowayan, Naveed Ahmad, Ameeduzzafar Zafar, Mohammed Elkomy
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Pharmaceutics
Subjects:
paliperidone
polycaprolactone nanoparticles
controlled release
stabilizer
chitosan coating
cytotoxicity
Online Access:https://www.mdpi.com/1999-4923/12/2/160

Internet

https://www.mdpi.com/1999-4923/12/2/160

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