S1 constrains S4 in the voltage sensor domain of Kv7.1 K+ channels.

S1 constrains S4 in the voltage sensor domain of Kv7.1 K+ channels.

Voltage-gated K(+) channels comprise a central pore enclosed by four voltage-sensing domains (VSDs). While movement of the S4 helix is known to couple to channel gate opening and closing, the nature of S4 motion is unclear. Here, we substituted S4 residues of Kv7.1 channels by cysteine and recorded...

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Bibliographic Details
Main Authors: Yoni Haitin, Ilanit Yisharel, Eti Malka, Liora Shamgar, Hella Schottelndreier, Asher Peretz, Yoav Paas, Bernard Attali
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2275789?pdf=render

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http://europepmc.org/articles/PMC2275789?pdf=render

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