Styryl-based and tricyclic compounds as potential anti-prion agents.
Prion diseases currently have no effective therapy. These illnesses affect both animal and human populations, and are characterized by the conformational change of a normal self protein PrP(C) (C for cellular) to a pathological and infectious conformer, PrP(Sc) (Sc for scrapie). We used a well chara...
| Hoofdauteurs: | , , , , , |
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| Formaat: | Artikel |
| Taal: | English |
| Gepubliceerd in: |
Public Library of Science (PLoS)
2011-01-01
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| Reeks: | PLoS ONE |
| Online toegang: | http://europepmc.org/articles/PMC3172287?pdf=render |