Pharmacokinetic Interpretation of Applying Local Drug Delivery System for the Treatment of Deep Surgical Site Infection in the Spine

Pharmacokinetic Interpretation of Applying Local Drug Delivery System for the Treatment of Deep Surgical Site Infection in the Spine

Surgical site infections (SSIs) after spinal surgery present significant challenges, including poor antibiotic penetration and biofilm formation on implants, leading to frequent treatment failures. Polymethylmethacrylate (PMMA) is widely used for localized drug delivery in bone infections, yet quant...

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Bibliographic Details
Main Authors: Ahmad Khalid Madadi, Moon-Jun Sohn
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Pharmaceutics
Subjects:
surgical site infection
drug delivery system
polymethylmehthacrylate (PMMA)
drug release kinetic
sustained release
antibiotics-loaded bone cement
Online Access:https://www.mdpi.com/1999-4923/16/1/94

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https://www.mdpi.com/1999-4923/16/1/94

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