IFNγ and iNOS-Mediated Alterations in the Bone Marrow and Thymus and Its Impact on Mycobacterium avium-Induced Thymic Atrophy

IFNγ and iNOS-Mediated Alterations in the Bone Marrow and Thymus and Its Impact on Mycobacterium avium-Induced Thymic Atrophy

Disseminated infection with the high virulence strain of Mycobacterium avium 25291 leads to progressive thymic atrophy. We previously showed that M. avium-induced thymic atrophy results from increased glucocorticoid levels that synergize with nitric oxide (NO) produced by interferon gamma (IFNγ) act...

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Bibliographic Details
Main Authors: Palmira Barreira-Silva, Rita Melo-Miranda, Claudia Nobrega, Susana Roque, Cláudia Serre-Miranda, Margarida Borges, Gisela Armada, Daniela de Sá Calçada, Samuel M. Behar, Rui Appelberg, Margarida Correia-Neves
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
thymus premature atrophy
Mycobacterium avium infection
IFN gamma
nitric oxide
BM T cell precursors
thymocyte differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.696415/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.696415/full

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