Titration of C-5 Sterol Desaturase Activity Reveals Its Relationship to Candida albicans Virulence and Antifungal Susceptibility Is Dependent upon Host Immune Status

Titration of C-5 Sterol Desaturase Activity Reveals Its Relationship to Candida albicans Virulence and Antifungal Susceptibility Is Dependent upon Host Immune Status

ABSTRACT The azole antifungals inhibit sterol 14α-demethylase (S14DM), which depletes cellular ergosterol and promotes synthesis of the dysfunctional lipid 14α-methylergosta-8,24(28)-dien-3β,6α-diol, ultimately arresting growth. Mutations that inactivate sterol Δ5,6-desaturase (Erg3p), the enzyme th...

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Bibliographic Details
Main Authors: Jessica Regan, Christian DeJarnette, Arturo Luna-Tapia, Josie E. Parker, Parker Reitler, Stacey Barnett, Katie M. Tucker, Steven L. Kelly, Glen E. Palmer
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:mBio
Subjects:
antifungal efficacy
C-5 sterol desaturase
Candida albicans
ERG3
fluconazole
pathogenicity
Online Access:https://journals.asm.org/doi/10.1128/mbio.00115-22

Internet

https://journals.asm.org/doi/10.1128/mbio.00115-22

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