A microbially produced AhR ligand promotes a Tph1-driven tolerogenic program in multiple sclerosis

A microbially produced AhR ligand promotes a Tph1-driven tolerogenic program in multiple sclerosis

Abstract Multiple sclerosis is a debilitating autoimmune disease, characterized by chronic inflammation of the central nervous system. While the significance of the gut microbiome on multiple sclerosis pathogenesis is established, the underlining mechanisms are unknown. We found that serum levels of...

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Bibliographic Details
Main Authors: Teresa Zelante, Giuseppe Paolicelli, Francesca Fallarino, Marco Gargaro, Gianluca Vascelli, Marco De Zuani, Jan Fric, Petra Laznickova, Marcela Hortova Kohoutkova, Antonio Macchiarulo, Daniela Dolciami, Giuseppe Pieraccini, Lorenzo Gaetani, Giulia Scalisi, Caterina Trevisan, Barbara Frossi, Carlo Pucillo, Antonella De Luca, Emilia Nunzi, Roberta Spaccapelo, Marilena Pariano, Monica Borghi, Francesca Boscaro, Riccardo Romoli, Andrea Mancini, Lucia Gentili, Giorgia Renga, Claudio Costantini, Matteo Puccetti, Stefano Giovagnoli, Maurizio Ricci, Martina Antonini, Paolo Calabresi, Paolo Puccetti, Massimiliano Di Filippo, Luigina Romani
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Mast cells
Aryl hydrocarbon receptor
Serotonin
3-IAld
Multiple sclerosis
Online Access:https://doi.org/10.1038/s41598-024-57400-8

Internet

https://doi.org/10.1038/s41598-024-57400-8

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