Topical tissue nanotransfection of Prox1 is effective in the prophylactic management of lymphedema

Topical tissue nanotransfection of Prox1 is effective in the prophylactic management of lymphedema

Lymphedema is chronic limb swelling resulting from lymphatic dysfunction. There is no cure for the disease. Clinically, a preventive surgical approach called immediate lymphatic reconstruction (ILR) has gained traction. Experimental gene-based therapeutic approaches (e.g., using viral vectors) have...

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Bibliographic Details
Main Authors: Ganesh Mohan, Imran Khan, Colby R. Neumann, Miguel D. Jorge, Shahnur Ahmed, Luci Hulsman, Mithun Sinha, Gayle M. Gordillo, Chandan K. Sen, Aladdin H. Hassanein
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
lymphedema
mice tail lymphedema model
Prox1
Vegf-C
tissue nanotransfection
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253124000088

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http://www.sciencedirect.com/science/article/pii/S2162253124000088

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