The immune checkpoint molecule, VTCN1/B7-H4, guides differentiation and suppresses proinflammatory responses and MHC class I expression in an embryonic stem cell-derived model of human trophoblast

The immune checkpoint molecule, VTCN1/B7-H4, guides differentiation and suppresses proinflammatory responses and MHC class I expression in an embryonic stem cell-derived model of human trophoblast

The placenta acts as a protective barrier to pathogens and other harmful substances present in the maternal circulation throughout pregnancy. Disruption of placental development can lead to complications of pregnancy such as preeclampsia, intrauterine growth retardation and preterm birth. In previou...

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Bibliographic Details
Main Authors: Jie Zhou, Yuchen Tian, Ying Qu, Madyson Williams, Ye Yuan, Rowan M. Karvas, Megan A. Sheridan, Laura C. Schulz, Toshihiko Ezashi, Michael R. Roberts, Danny J. Schust
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Endocrinology
Subjects:
embryonic stem cells
placental development
B7-H4/VTCN1
classical major histocompatibility complex class I molecules (MHC-I)
natural killer cells
HLA-G
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1069395/full

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https://www.frontiersin.org/articles/10.3389/fendo.2023.1069395/full

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