Recruitment of α4β7 monocytes and neutrophils to the brain in experimental colitis is associated with elevated cytokines and anxiety-like behavior

Recruitment of α4β7 monocytes and neutrophils to the brain in experimental colitis is associated with elevated cytokines and anxiety-like behavior

Abstract Background Behavioral comorbidities, such as anxiety and depression, are a prominent feature of IBD. The signals from the inflamed gut that cause changes in the brain leading to these behavioral comorbidities remain to be fully elucidated. We tested the hypothesis that enhanced leukocyte–ce...

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Bibliographic Details
Main Authors: Nina L. Cluny, Kewir D. Nyuyki, Wagdi Almishri, Lateece Griffin, Benjamin H. Lee, Simon A. Hirota, Quentin J. Pittman, Mark G. Swain, Keith A. Sharkey
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Journal of Neuroinflammation
Subjects:
MAdCAM-1
Neutrophil
Monocyte
Colitis
Interleukin 1β
Anxiety-like behavior
Online Access:https://doi.org/10.1186/s12974-022-02431-z

Internet

https://doi.org/10.1186/s12974-022-02431-z

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