An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variants

An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variants

Abstract The wide transmission and host adaptation of SARS-CoV-2 have led to the rapid accumulation of mutations, posing significant challenges to the effectiveness of vaccines and therapeutic antibodies. Although several neutralizing antibodies were authorized for emergency clinical use, convalesce...

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Bibliographic Details
Main Authors: Xiaojing Chi, Xinhui Zhang, Shengnan Pan, Yanying Yu, Yujin Shi, Tianli Lin, Huarui Duan, Xiuying Liu, Wenfang Chen, Xuehua Yang, Lan Chen, Xiaoqian Dong, Lili Ren, Qiang Ding, Jianwei Wang, Wei Yang
Format: Article
Language:English
Published: Nature Publishing Group 2022-02-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-022-00912-4

Internet

https://doi.org/10.1038/s41392-022-00912-4

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