Pyruvate dehydrogenase kinase 1–dependent metabolic reprogramming: A promising target for postmenopausal osteoporosis treatment

Pyruvate dehydrogenase kinase 1–dependent metabolic reprogramming: A promising target for postmenopausal osteoporosis treatment

Postmenopausal osteoporosis (PMOP) is a classic endocrine disorder characterized by an imbalance between bone formation and bone resorption. Abnormal glucose metabolic reprogramming has been widely explored in endocrine disorders, but its role in PMOP has not been elucidated. Icariin (ICA), as a bio...

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Bibliographic Details
Main Authors: Dingbang Xie, Yunteng Xu, Yimin Zhang, Wanping Cai, Xin Lan, Hui Yan
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Postmenopausal osteoporosis
Osteoclastogenesis
Icariin
Metabolic reprogramming
Pyruvate dehydrogenase subunit alpha pSer232
Pyruvate dehydrogenase kinase 1
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223001993

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http://www.sciencedirect.com/science/article/pii/S0753332223001993

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