Chemoenzymatic synthesis of sulfur-linked sugar polymers as heparanase inhibitors

Chemoenzymatic synthesis of sulfur-linked sugar polymers as heparanase inhibitors

Heparin is a family of complex carbohydrates binding to proteins to modulate cell activities. Here the authors report the synthesis, and conformations simulations of S-linked hemi-A heparosan [GlcA-S-GlcNAc]n, a thio-glycosidic uncleavable polysaccharide, and test it as human heparanase inhibitor.

Bibliographic Details
Main Authors: Peng He, Xing Zhang, Ke Xia, Dixy E. Green, Sultan Baytas, Yongmei Xu, Truong Pham, Jian Liu, Fuming Zhang, Andrew Almond, Robert J. Linhardt, Paul L. DeAngelis
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34788-3

Internet

https://doi.org/10.1038/s41467-022-34788-3

Similar Items