iPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors

iPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors

Abstract Background Dozens of transplants generated from pluripotent stem cells are currently in clinical trials. The creation of patient-specific iPSCs makes personalized therapy possible due to their main advantage of immunotolerance. However, some reports have claimed recently that aberrant gene...

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Bibliographic Details
Main Authors: Margarita E. Bogomiakova, Elizaveta K. Sekretova, Ksenia S. Anufrieva, Polina O. Khabarova, Anastasia N. Kazakova, Pavel A. Bobrovsky, Tatiana V. Grigoryeva, Artem V. Eremeev, Olga S. Lebedeva, Alexandra N. Bogomazova, Maria A. Lagarkova
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Stem Cell Research & Therapy
Subjects:
Autologous iPSCs
NK-cells
Differentiation
HLA-I
Beta-2-microglobulin
Immunogenicity
Online Access:https://doi.org/10.1186/s13287-023-03308-5

Internet

https://doi.org/10.1186/s13287-023-03308-5

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