iPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors
Abstract Background Dozens of transplants generated from pluripotent stem cells are currently in clinical trials. The creation of patient-specific iPSCs makes personalized therapy possible due to their main advantage of immunotolerance. However, some reports have claimed recently that aberrant gene...
Main Authors: | Margarita E. Bogomiakova, Elizaveta K. Sekretova, Ksenia S. Anufrieva, Polina O. Khabarova, Anastasia N. Kazakova, Pavel A. Bobrovsky, Tatiana V. Grigoryeva, Artem V. Eremeev, Olga S. Lebedeva, Alexandra N. Bogomazova, Maria A. Lagarkova |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-04-01
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Series: | Stem Cell Research & Therapy |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13287-023-03308-5 |
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