Iron Administration Overcomes Resistance to Erastin-Mediated Ferroptosis in Ovarian Cancer Cells

Iron Administration Overcomes Resistance to Erastin-Mediated Ferroptosis in Ovarian Cancer Cells

ObjectivesDeveloping novel therapeutic approaches to defeat chemoresistance is the major goal of ovarian cancer research. Induction of ferroptosis has shown promising antitumor effects in ovarian cancer cells, but the existence of still undefined genetic and metabolic determinants of susceptibility...

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Bibliographic Details
Main Authors: Anna Martina Battaglia, Alessandro Sacco, Ida Daniela Perrotta, Maria Concetta Faniello, Mariangela Scalise, Daniele Torella, Sonia Levi, Francesco Costanzo, Flavia Biamonte
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
ferroptosis
ovarian cancer
iron
erastin
chemoresistance
mitochondrial dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.868351/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.868351/full

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