RhoC regulates radioresistance via crosstalk of ROCK2 with the DNA repair machinery in cervical cancer

RhoC regulates radioresistance via crosstalk of ROCK2 with the DNA repair machinery in cervical cancer

Abstract Background Radioresistance remains a challenge to the successful treatment of various tumors. Intrinsic factors like alterations in signaling pathways regulate response to radiation. RhoC, which has been shown to modulate several tumor phenotypes has been investigated in this report for its...

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Bibliographic Details
Main Authors: Annapurna Pranatharthi, Pavana Thomas, Avinash H. Udayashankar, Chandra Bhavani, Srinag Bangalore Suresh, Sudhir Krishna, Jayashree Thatte, Nirmala Srikantia, Cecil R. Ross, Sweta Srivastava
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Radioresistance
DNA repair
RhoC ROCK2
Cervical cancer
Online Access:http://link.springer.com/article/10.1186/s13046-019-1385-7

Internet

http://link.springer.com/article/10.1186/s13046-019-1385-7

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