Aldose Reductase (AR) Mediates and Perivascular Adipose Tissue (PVAT) Modulates Endothelial Dysfunction of Short-Term High-Fat Diet Feeding in Mice

Aldose Reductase (AR) Mediates and Perivascular Adipose Tissue (PVAT) Modulates Endothelial Dysfunction of Short-Term High-Fat Diet Feeding in Mice

Increased adiposity of both visceral and perivascular adipose tissue (PVAT) depots is associated with an increased risk of diabetes and cardiovascular disease (CVD). Under healthy conditions, PVAT modulates vascular tone via the release of PVAT-derived relaxing factors, including adiponectin and lep...

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Bibliographic Details
Main Authors: Daniel J. Conklin, Petra Haberzettl, Kenneth G. MacKinlay, Daniel Murphy, Lexiao Jin, Fangping Yuan, Sanjay Srivastava, Aruni Bhatnagar
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Metabolites
Subjects:
adiposity
cardiovascular disease
endothelium
leptin
lipid-derived aldehydes
nitric oxide
Online Access:https://www.mdpi.com/2218-1989/13/12/1172

Internet

https://www.mdpi.com/2218-1989/13/12/1172

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