The Interaction of CD97/ADGRE5 With β-Catenin in Adherens Junctions Is Lost During Colorectal Carcinogenesis

The Interaction of CD97/ADGRE5 With β-Catenin in Adherens Junctions Is Lost During Colorectal Carcinogenesis

The adhesion G-protein-coupled receptor CD97/ADGRE5 is present in adherens junctions of human normal intestinal cells and upregulated in colorectal carcinomas. Here, we examined whether CD97 directly interacts with junctional proteins in normal and malignant colorectal tissue. We identified an assoc...

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Bibliographic Details
Main Authors: Doris Hilbig, Norman Dietrich, Elke Wandel, Susann Gonsior, Doreen Sittig, Jörg Hamann, Gabriela Aust
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Oncology
Subjects:
ADGRE5
CD97
adhesion-GPCR
β-catenin
adherens junction
colorectal carcinoma
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00182/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00182/full

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