A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs

A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs

Summary: Single-nucleotide polymorphisms (SNPs) near the ERAP2 gene are associated with various autoimmune conditions, as well as protection against lethal infections. Due to high linkage disequilibrium, numerous trait-associated SNPs are correlated with ERAP2 expression; however, their functional m...

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Bibliographic Details
Main Authors: Wouter J. Venema, Sanne Hiddingh, Jorg van Loosdregt, John Bowes, Brunilda Balliu, Joke H. de Boer, Jeannette Ossewaarde-van Norel, Susan D. Thompson, Carl D. Langefeld, Aafke de Ligt, Lars T. van der Veken, Peter H.L. Krijger, Wouter de Laat, Jonas J.W. Kuiper
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Cell Genomics
Subjects:
ERAP2
GWAS
autoimmunity
SNP
eQTL
rs2248374
Online Access:http://www.sciencedirect.com/science/article/pii/S2666979X2300304X

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http://www.sciencedirect.com/science/article/pii/S2666979X2300304X

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