Methylation-directed regulatory networks determine enhancing and silencing of mutation disease driver genes and explain inter-patient expression variation

Methylation-directed regulatory networks determine enhancing and silencing of mutation disease driver genes and explain inter-patient expression variation

Abstract Background Common diseases manifest differentially between patients, but the genetic origin of this variation remains unclear. To explore possible involvement of gene transcriptional-variation, we produce a DNA methylation-oriented, driver-gene-wide dataset of regulatory elements in human g...

Full description

Bibliographic Details
Main Authors: Yifat Edrei, Revital Levy, Daniel Kaye, Anat Marom, Bernhard Radlwimmer, Asaf Hellman
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Genome Biology
Subjects:
Gene regulation
Gene regulatory-domains
DNA methylations
Enhancers
Silencers
Cis-regulatory elements
Online Access:https://doi.org/10.1186/s13059-023-03094-6

Internet

https://doi.org/10.1186/s13059-023-03094-6

Similar Items