The angiotensin-(1-7)/Mas axis counteracts angiotensin II-dependent and –independent pro-inflammatory signaling in human vascular smooth muscle cells

The angiotensin-(1-7)/Mas axis counteracts angiotensin II-dependent and –independent pro-inflammatory signaling in human vascular smooth muscle cells

Background and aims: Targeting inflammation is nowadays considered as a challenging pharmacological strategy to prevent or delay the development of vascular diseases. Angiotensin-(1-7) is a member of the renin-angiotensin system (RAS) that binds Mas receptors and has gained growing attention in the...

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Bibliographic Details
Main Authors: Laura A Villalobos, Álvaro San Hipólito, Mariella Ramos-González, Elena Cercas, Susana Vallejo, Alejandra Romero, Tania Romacho, Raffaele Carraro, Carlos F Sánchez-Ferrer, Concepción Peiró
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Pharmacology
Subjects:
Cytokines
Inflammation
Interleukin-1beta
vascular smooth muscle
cell signalling
inducible nitric oxide synthase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00482/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00482/full

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