miR-16-5p Suppresses Progression and Invasion of Osteosarcoma via Targeting at Smad3

BackgroundMicroRNAs are known to regulate carcinogenesis of osteosarcoma. Although, miR-16-5p is known to exert inhibitory effects on several forms of cancers, its effects on the growth and invasion of osteosarcoma have not been studied.MethodsWe collected human osteosarcoma specimens and adjacent t...

Full description

Bibliographic Details
Main Authors: Zhijian Gu, Zhikun Li, Ruijun Xu, Xiaodong Zhu, Ruixi Hu, Yonghua Xue, Wei Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01324/full