<it>scribble </it>mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

<it>scribble </it>mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

<p>Abstract</p> <p>Background</p> <p>Metastatic neoplasias are characterized by excessive cell proliferation and disruptions to apico-basal cell polarity and tissue architecture. Understanding how alterations in cell polarity can impact upon tumour development is, there...

Full description

Bibliographic Details
Main Authors:	Richardson Helena E, Amin Nancy, Goulding Karen R, Leong Gregory R, Brumby Anthony M
Format:	Article
Language:	English
Published:	BMC 2009-09-01
Series:	BMC Biology
Online Access:	http://www.biomedcentral.com/1741-7007/7/62

Similar Items

An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation.
by: Carine Rosse, et al.
Published: (2009-11-01)

Pak1 and PP2A antagonize aPKC function to support cortical tension induced by the Crumbs-Yurt complex
by: Cornelia Biehler, et al.
Published: (2021-07-01)

Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis.
by: Nicole A Kaplan, et al.
Published: (2011-04-01)

MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis
by: Kenji Matsuzawa, et al.
Published: (2021-03-01)

aPKC phosphorylation of HDAC6 results in increased deacetylation activity.
by: Yifeng Du, et al.
Published: (2015-01-01)

Nup358 interacts with Dishevelled and aPKC to regulate neuronal polarity
by: Pankhuri Vyas, et al.
Published: (2013-10-01)

Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC.
by: Salah Elias, et al.
Published: (2015-05-01)

A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues
by: Linda M. Parsons, et al.
Published: (2017-08-01)

Stepwise polarisation of developing bilayered epidermis is mediated by aPKC and E-cadherin in zebrafish
by: Prateek Arora, et al.
Published: (2020-01-01)

aPKC-mediated displacement and actomyosin-mediated retention polarize Miranda in Drosophila neuroblasts
by: Matthew Robert Hannaford, et al.
Published: (2018-01-01)

The aPKC-CBP Pathway Regulates Adult Hippocampal Neurogenesis in an Age-Dependent Manner
by: Ayden Gouveia, et al.
Published: (2016-10-01)

aPKC: the Kinase that Phosphorylates Cell Polarity [version 1; referees: 2 approved]
by: Yang Hong
Published: (2018-06-01)

The aPKC-CBP Pathway Regulates Post-stroke Neurovascular Remodeling and Functional Recovery
by: Ayden Gouveia, et al.
Published: (2017-12-01)

Par-complex aPKC and Par3 cross-talk with innate immunity NF-κB pathway in epithelial cells
by: Radia Forteza, et al.
Published: (2013-12-01)

Par-complex aPKC and Par3 cross-talk with innate immunity NF-κB pathway in epithelial cells
by: Radia Forteza, et al.
Published: (2013-10-01)

Shank2 Binds to aPKC and Controls Tight Junction Formation with Rap1 Signaling during Establishment of Epithelial Cell Polarity
by: Kazunori Sasaki, et al.
Published: (2020-04-01)

Disruption of the Cdc42/Par6/aPKC or Dlg/Scrib/Lgl Polarity Complex Promotes Epithelial Proliferation via Overlapping Mechanisms.
by: Gregory V Schimizzi, et al.
Published: (2016-01-01)

Activation of Discs large by aPKC aligns the mitotic spindle to the polarity axis during asymmetric cell division
by: Ognjen Golub, et al.
Published: (2017-11-01)

A modifier screen in the <it>Drosophila </it>eye reveals that <it>aPKC </it>interacts with <it>Glued </it>during central synapse formation
by: Ma Lisha, et al.
Published: (2009-01-01)

aPKCι promotes gallbladder cancer tumorigenesis and gemcitabine resistance by competing with Nrf2 for binding to Keap1
by: Li Tian, et al.
Published: (2019-04-01)

aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability
by: Meghan Riddell, et al.
Published: (2018-12-01)

Scribble and α-Catenin cooperatively regulate epithelial homeostasis and growth
by: Yunxian Huang, et al.
Published: (2022-09-01)

Loss of FBP1 by aPKC-ι/Snail Pathway-Mediated Repression Promotes Invasion and Aerobic Glycolysis of Intrahepatic Cholangiocarcinoma
by: Meng Gao, et al.
Published: (2021-12-01)

Loss of aPKCλ in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains.
by: Tomoyuki Yamanaka, et al.
Published: (2013-01-01)

Altered Expression of Par3, aPKC-λ, and Lgl1 in Hippocampus in Kainic Acid-Induced Status Epilepticus Rat Model
by: Chen Zhang, et al.
Published: (2021-12-01)

ScribbleCDNet: Change detection on high-resolution remote sensing imagery with scribble interaction
by: Zhipan Wang, et al.
Published: (2024-04-01)

Loss of Cell Adhesion Increases Tumorigenic Potential of Polarity Deficient Scribble Mutant Cells.
by: Indrayani Waghmare, et al.
Published: (2016-01-01)

Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway
by: Pei-Jie Zhou, et al.
Published: (2017-10-01)

Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation
by: Mini P. Sajan, et al.
Published: (2015-01-01)

The brachyceran de novo gene PIP82, a phosphorylation target of aPKC, is essential for proper formation and maintenance of the rhabdomeric photoreceptor apical domain in Drosophila.
by: Andrew C Zelhof, et al.
Published: (2020-06-01)

CD74-dependent Deregulation of the Tumor Suppressor Scribble in Human Epithelial and Breast Cancer Cells
by: Gergana Metodieva, et al.
Published: (2013-06-01)

Caenorhabditis elegans LET-413 Scribble is essential in the epidermis for growth, viability, and directional outgrowth of epithelial seam cells.
by: Amalia Riga, et al.
Published: (2021-10-01)

The Plough and the Pen. Of the Scribbling Hoe and Library of Yams
by: Niyi Osundare
Published: (2019-05-01)

Scribble, Lgl1, and myosin IIA interact with α-/β-catenin to maintain epithelial junction integrity
by: Maha Abedrabbo, et al.
Published: (2023-12-01)

Dynamic MAPK signaling activity underlies a transition from growth arrest to proliferation in Drosophila scribble mutant tumors
by: Tiantian Ji, et al.
Published: (2019-08-01)

Scribble scrabble : ready-in-a-minute math games /
by: 207990 Sharp, Richard M., et al.
Published: (1995)

Learning about critical phenomena from scribbles and sandpiles*
by: Kassel Adrien
Published: (2015-10-01)

Afadin couples RAS GTPases to the polarity rheostat Scribble
by: Marilyn Goudreault, et al.
Published: (2022-08-01)

The atrical scribblings in babies' gestures: a Bakhtinian study
by: Viviane Maria Alessi, et al.
Published: (2019-03-01)

Scribbled Optimizes BMP Signaling through Its Receptor Internalization to the Rab5 Endosome and Promote Robust Epithelial Morphogenesis.
by: Jinghua Gui, et al.
Published: (2016-11-01)