Exploring Membrane Binding Targets of Disordered Human Tau Aggregates on Lipid Rafts Using Multiscale Molecular Dynamics Simulations

Exploring Membrane Binding Targets of Disordered Human Tau Aggregates on Lipid Rafts Using Multiscale Molecular Dynamics Simulations

The self-aggregation of tau, a microtubule-binding protein, has been linked to the onset of Alzheimer’s Disease. Recent studies indicate that the disordered tau aggregates, or oligomers, are more toxic than the ordered fibrils found in the intracellular neurofibrillary tangles of tau. At present, de...

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Bibliographic Details
Main Authors: Kwan H. Cheng, Angela Graf, Amber Lewis, Thuong Pham, Aakriti Acharya
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Membranes
Subjects:
amyloidogenic protein
protein aggregation
neurodegenerative diseases
phase-separated lipid bilayer
neuronal membranes
MD simulations
Online Access:https://www.mdpi.com/2077-0375/12/11/1098

Internet

https://www.mdpi.com/2077-0375/12/11/1098

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