Microsatellite instability screening in colorectal carcinoma: immunohistochemical analysis of MMR proteins in correlation with clinicopathological features and Ki-67 protein expression

Microsatellite instability screening in colorectal carcinoma: immunohistochemical analysis of MMR proteins in correlation with clinicopathological features and Ki-67 protein expression

Abstract Background Defects in mismatch repair (MMR) system or microsatellite instability (MSI) and detected in colorectal carcinoma (CRC), both in sporadic and more frequently in hereditary cases. Immunohistochemistry (IHC) is the most frequent method for MMR protein deficiency screening in CRCs. I...

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Bibliographic Details
Main Authors: Noha N. Yassen, Dalia M. Abouelfadl, Naglaa F. Abbas, Ahmed S. A. Soliman, Marwa E. Shabana
Format: Article
Language:English
Published: SpringerOpen 2023-10-01
Series:Bulletin of the National Research Centre
Subjects:
Colorectal carcinoma
Mismatch repair
Microsatellite instability-Ki-67
Online Access:https://doi.org/10.1186/s42269-023-01132-8

Internet

https://doi.org/10.1186/s42269-023-01132-8

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