Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth

Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth

Abstract Background Mitochondrial fusion and fission proteins have been nominated as druggable targets in cancer. Whether their inhibition is efficacious in triple negative breast cancer (TNBC) that almost invariably develops chemoresistance is unknown. Methods We used a combination of bioinformatic...

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Bibliographic Details
Main Authors: Margherita Zamberlan, Amandine Boeckx, Florian Muller, Federica Vinelli, Olivier Ek, Caterina Vianello, Emeline Coart, Keitaro Shibata, Aurélie Christian, Francesca Grespi, Marta Giacomello, Ingrid Struman, Luca Scorrano, Stéphanie Herkenne
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Experimental & Clinical Cancer Research
Online Access:https://doi.org/10.1186/s13046-022-02304-6

Internet

https://doi.org/10.1186/s13046-022-02304-6

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