Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells

Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells

Autophagy is a cellular process for recycling cell constituents, and is essential for T cell activation, but its function in T cell polarization is still unclear. Here the authors show that autophagy induces the degradation of transcription factor PU.1 to negatively modulate TH9 homeostasis and anti...

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Bibliographic Details
Main Authors: Thaiz Rivera Vargas, Zhijian Cai, Yingying Shen, Magalie Dosset, Isis Benoit-Lizon, Tiffany Martin, Aurélie Roussey, Richard A. Flavell, François Ghiringhelli, Lionel Apetoh
Format: Article
Language:English
Published: Nature Portfolio 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00468-w

Internet

https://doi.org/10.1038/s41467-017-00468-w

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