S6K1 Alternative Splicing Modulates Its Oncogenic Activity and Regulates mTORC1

S6K1 Alternative Splicing Modulates Its Oncogenic Activity and Regulates mTORC1

Ribosomal S6 kinase 1 (S6K1) is a major mTOR downstream signaling molecule that regulates cell size and translation efficiency. Here, we report that short isoforms of S6K1 are overproduced in breast cancer cell lines and tumors. Overexpression of S6K1 short isoforms induces transformation of human b...

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Bibliographic Details
Main Authors: Vered Ben-Hur, Polina Denichenko, Zahava Siegfried, Avi Maimon, Adrian Krainer, Ben Davidson, Rotem Karni
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712004172

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http://www.sciencedirect.com/science/article/pii/S2211124712004172

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