Heterogeneity of tumour mutational burden in metastatic NSCLC demonstrated by endobronchial ultrasound sampling

Heterogeneity of tumour mutational burden in metastatic NSCLC demonstrated by endobronchial ultrasound sampling

IntroductionTumour mutational burden (TMB) is an important emerging biomarker for immune checkpoint inhibitors (ICI). The stability of TMB values across distinct EBUS tumour regions is not well defined in advanced lung cancer patients.MethodsThis study included a whole-genome sequencing cohort (n=11...

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Bibliographic Details
Main Authors: Tracy L. Leong, Christian Aloe, Savreet Aujla, Hao Wang, Velimir Gayevskiy, Marie-Liesse Asselin-Labat, Lesley-Ann Gray, Daniel Steinfort, Steven Bozinovski
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Oncology
Subjects:
bronchoscopy
biomarker
lung cancer
tumour mutational burden
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1150349/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1150349/full

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