Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes

Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes

Abstract Background Neutralising antibodies to sclerostin (Scl-Ab) have shown significant potential to induce bone formation and decrease bone resorption, increase strength and substantially reduce fracture risk in animal studies and clinical trials. Mechanical loading negatively regulates sclerosti...

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Bibliographic Details
Main Authors: H. Allison, G. Holdsworth, L. M. McNamara
Format: Article
Language:English
Published: BMC 2020-11-01
Series:BMC Molecular and Cell Biology
Subjects:
Mechanobiology
Estrogen deficiency
Sclerostin antibody
Osteoclastogenesis
Oscillatory fluid flow
Online Access:http://link.springer.com/article/10.1186/s12860-020-00322-w

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http://link.springer.com/article/10.1186/s12860-020-00322-w

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