Intranasal Boosting with Spike Fc-RBD of Wild-Type SARS-CoV-2 Induces Neutralizing Antibodies against Omicron Subvariants and Reduces Viral Load in the Nasal Turbinate of Mice

Intranasal Boosting with Spike Fc-RBD of Wild-Type SARS-CoV-2 Induces Neutralizing Antibodies against Omicron Subvariants and Reduces Viral Load in the Nasal Turbinate of Mice

The emergence of new immune-evasive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and subvariants outpaces the development of vaccines specific against the dominant circulating strains. In terms of the only accepted immune correlate of protection, the inactivated whole-virion...

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Bibliographic Details
Main Authors: Jian-Piao Cai, Cuiting Luo, Kun Wang, Hehe Cao, Lin-Lei Chen, Xiaojuan Zhang, Yuting Han, Feifei Yin, Anna Jinxia Zhang, Hin Chu, Shuofeng Yuan, Kin-Hang Kok, Kelvin Kai-Wang To, Honglin Chen, Zhiwei Chen, Dong-Yan Jin, Kwok-Yung Yuen, Jasper Fuk-Woo Chan
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Viruses
Subjects:
COVID-19
SARS-CoV-2
Omicron variant
BA.5.2
XBB.1
Fc-RBD
Online Access:https://www.mdpi.com/1999-4915/15/3/687

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https://www.mdpi.com/1999-4915/15/3/687

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