Upregulated Connexin 43 Induced by Loss-of-Functional S284L-Mutant α4 Subunit of Nicotinic ACh Receptor Contributes to Pathomechanisms of Autosomal Dominant Sleep-Related Hypermotor Epilepsy

Upregulated Connexin 43 Induced by Loss-of-Functional S284L-Mutant α4 Subunit of Nicotinic ACh Receptor Contributes to Pathomechanisms of Autosomal Dominant Sleep-Related Hypermotor Epilepsy

To study the pathomechanism and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy (ADSHE), this study determined functional abnormalities of glutamatergic transmission in the thalamocortical motor pathway, from the reticular thalamic nucleus (RTN), motor thalamic nuclei (MoTN)...

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Bibliographic Details
Main Authors: Kouji Fukuyama, Masashi Fukuzawa, Ruri Okubo, Motohiro Okada
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Pharmaceuticals
Subjects:
idiopathic epilepsy
zonisamide
microdialysis
connexin
hemichannel
Online Access:https://www.mdpi.com/1424-8247/13/4/58

Internet

https://www.mdpi.com/1424-8247/13/4/58

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