CRISPR/Cas9-Induced Disruption of Paraflagellar Rod Protein 1 and 2 Genes in <named-content content-type="genus-species">Trypanosoma cruzi</named-content> Reveals Their Role in Flagellar Attachment

CRISPR/Cas9-Induced Disruption of Paraflagellar Rod Protein 1 and 2 Genes in <named-content content-type="genus-species">Trypanosoma cruzi</named-content> Reveals Their Role in Flagellar Attachment

ABSTRACT Trypanosoma cruzi is the etiologic agent of Chagas disease, and current methods for its genetic manipulation have been highly inefficient. We report here the use of the CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated gene 9) system for disrupting g...

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Bibliographic Details
Main Authors: Noelia Lander, Zhu-Hong Li, Sayantanee Niyogi, Roberto Docampo
Format: Article
Language:English
Published: American Society for Microbiology 2015-09-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.01012-15

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