Viral Determinants of miR-122-Independent Hepatitis C Virus Replication

Viral Determinants of miR-122-Independent Hepatitis C Virus Replication

ABSTRACT Hepatitis C virus (HCV) replication requires binding of the liver-specific microRNA (miRNA) miR-122 to two sites in the HCV 5′ untranslated region (UTR). Although we and others have shown that viral genetics impact the amount of active miR-122 required for replication, it is unclear if HCV...

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Bibliographic Details
Main Authors: Sharon E. Hopcraft, Kristopher D. Azarm, Benjamin Israelow, Nicolas Lévêque, Megan C. Schwarz, Tien-Huei Hsu, Matthew T. Chambers, Marion Sourisseau, Bert L. Semler, Matthew J. Evans
Format: Article
Language:English
Published: American Society for Microbiology 2016-02-01
Series:mSphere
Subjects:
hepatitis C virus
microRNA
miR-122
CRISPR
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00009-15

Internet

https://journals.asm.org/doi/10.1128/mSphere.00009-15

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