IL-34 induces the differentiation of human monocytes into immunosuppressive macrophages. antagonistic effects of GM-CSF and IFNγ.

IL-34 induces the differentiation of human monocytes into immunosuppressive macrophages. antagonistic effects of GM-CSF and IFNγ.

IL-34 is a recently identified cytokine that signals via the M-CSF receptor and promotes monocyte survival. Depending on the environment, monocytes can differentiate into macrophages (Mφ) or dendritic cells (DC). A wide spectrum of Mφ and DC subsets, with distinct phenotypes and functions, has been...

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Bibliographic Details
Main Authors: Etienne D Foucher, Simon Blanchard, Laurence Preisser, Erwan Garo, Norbert Ifrah, Philippe Guardiola, Yves Delneste, Pascale Jeannin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3568045?pdf=render

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http://europepmc.org/articles/PMC3568045?pdf=render

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