Deterioration in cognitive control related mPFC function underlying development of treatment resistance in early psychosis

Deterioration in cognitive control related mPFC function underlying development of treatment resistance in early psychosis

Abstract One third of people with psychosis become antipsychotic treatment-resistant and the underlying mechanisms remain unclear. We investigated whether altered cognitive control function is a factor underlying development of treatment resistance. We studied 50 people with early psychosis at a bas...

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Bibliographic Details
Main Authors: Charlotte M. Crisp, Angad Sahni, Sze W. Pang, Lucy D. Vanes, Timea Szentgyorgyi, Bruno Averbeck, Rosalyn J. Moran, Sukhwinder S. Shergill
Format: Article
Language:English
Published: Nature Portfolio 2024-06-01
Series:Scientific Reports
Subjects:
Cognitive control
Treatment resistance
Schizophrenia
fMRI
Glutamate
Spectroscopy
Online Access:https://doi.org/10.1038/s41598-024-63474-1

Internet

https://doi.org/10.1038/s41598-024-63474-1

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