TPP Combined with DGUC as an Economic and Universal Process for Large-Scale Purification of AAV Vectors

TPP Combined with DGUC as an Economic and Universal Process for Large-Scale Purification of AAV Vectors

Adeno-associated virus (AAV) vectors have been commonly purified through density gradient ultracentrifugation (DGUC) or column chromatography methods. Although the DGUC method can efficiently separate the empty from the full virus particles, its application in large-scale AAV purification is hindere...

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Bibliographic Details
Main Authors: Zhe Yu, Siyun Zhou, Ningguang Luo, Ching Yi Ho, Min Chen, Haifeng Chen
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV purification
three-phase partitioning
TPP
baculovirus
gene therapy
density gradient ultracentrifugation
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050119301342

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http://www.sciencedirect.com/science/article/pii/S2329050119301342

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