A toxicology study of Csf2ra complementation and pulmonary macrophage transplantation therapy of hereditary PAP in mice

A toxicology study of Csf2ra complementation and pulmonary macrophage transplantation therapy of hereditary PAP in mice

Pulmonary macrophage transplantation (PMT) is a gene and cell transplantation approach in development as therapy for hereditary pulmonary alveolar proteinosis (hPAP), a surfactant accumulation disorder caused by mutations in CSF2RA/B (and murine homologs). We conducted a toxicology study of PMT of C...

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Main Authors: Paritha Arumugam, Brenna C. Carey, Kathryn A. Wikenheiser-Brokamp, Jeffrey Krischer, Matthew Wessendarp, Kenjiro Shima, Claudia Chalk, Jennifer Stock, Yan Ma, Diane Black, Michelle Imbrogno, Margaret Collins, Dan Justin Kalenda Yombo, Haripriya Sakthivel, Takuji Suzuki, Carolyn Lutzko, Jose A. Cancelas, Michelle Adams, Elizabeth Hoskins, Dawn Lowe-Daniels, Lilith Reeves, Anne Kaiser, Bruce C. Trapnell
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
lentiviral vector
Csf2ra complementation
surfactant
alveolar macrophage
hereditary PAP
toxicology
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050124000299

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http://www.sciencedirect.com/science/article/pii/S2329050124000299

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