Efficient mRNA-based Genetic Engineering of Human NK Cells with High-Affinity CD16 and CCR7 Augments Rituximab-induced ADCC against Lymphoma and Targets NK cell Migration Towards the Lymph Node Associated Chemokine CCL19

Efficient mRNA-based Genetic Engineering of Human NK Cells with High-Affinity CD16 and CCR7 Augments Rituximab-induced ADCC against Lymphoma and Targets NK cell Migration Towards the Lymph Node Associated Chemokine CCL19

For more than a decade, investigators have pursued methods to genetically engineer NK cells for use in clinical therapy against cancer. Despite considerable advances in viral transduction of hematopoietic stem cells and T cells, transduction efficiencies for NK cells have remained disappointingly lo...

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Bibliographic Details
Main Authors: Mattias eCarlsten, Emily eLevy, Amrita eKarambelkar, Linhong eLi, Robert eReger, Maria eBerg, Madhusudan ePeshwa, Richard eChilds
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Immunology
Subjects:
Gene Therapy
NK cells
cellular migration
Antibody-dependent cellular cytotoxicity
NK cell Immunotherapy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00105/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00105/full

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