iPSC-derived PSEN2 (N141I) astrocytes and microglia exhibit a primed inflammatory phenotype

iPSC-derived PSEN2 (N141I) astrocytes and microglia exhibit a primed inflammatory phenotype

Abstract Background Widescale evidence points to the involvement of glia and immune pathways in the progression of Alzheimer’s disease (AD). AD-associated iPSC-derived glial cells show a diverse range of AD-related phenotypic states encompassing cytokine/chemokine release, phagocytosis and morpholog...

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Bibliographic Details
Main Authors: Michael A. Sullivan, Samuel D. Lane, André D. J. McKenzie, Sarah R. Ball, Margaret Sunde, G. Gregory Neely, Cesar L. Moreno, Alexandra Maximova, Eryn L. Werry, Michael Kassiou
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Astrocytes
Glia
Alzheimer’s disease
Pro-inflammatory
iPSC
Online Access:https://doi.org/10.1186/s12974-023-02951-2

Internet

https://doi.org/10.1186/s12974-023-02951-2

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