Molecularly engineered tumor acidity-responsive plant toxin gelonin for safe and efficient cancer therapy

Due to the unsatisfactory therapeutic efficacy and inexorable side effects of small molecule antineoplastic agents, extensive efforts have been devoted to the development of more potent macromolecular agents with high specificity. Gelonin is a plant-derived protein toxin that exhibits robust antitum...

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Bibliographic Details
Main Authors: Guo-Bin Ding, Chenchen Zhu, Qian Wang, Huiyan Cao, Bin-Chun Li, Peng Yang, Roland H. Stauber, Guangjun Nie, Zhuoyu Li
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-12-01
Series:Bioactive Materials
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X22000664