Pan-cancer analysis of chromothripsis-related gene expression patterns indicates an association with tumor immune and therapeutic agent responses

Pan-cancer analysis of chromothripsis-related gene expression patterns indicates an association with tumor immune and therapeutic agent responses

Chromothripsis is a catastrophic event involving numerous chromosomal rearrangements in confined genomic regions of one or a few chromosomes, causing complex effects on cells via the extensive structural variation. The development of whole-genome sequencing (WGS) has promoted great progress in explo...

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Bibliographic Details
Main Authors: Qin Zhang, Lujie Yang, He Xiao, Zhaoqian Dang, Xunjie Kuang, Yanli Xiong, Jianwu Zhu, Zhou Huang, Mengxia Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
chromothripsis
tumor immunity
drug resistance
prognosis
immune checkpoint inhibitors therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1074955/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1074955/full

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