Conditional knockout of leptin receptor in neural stem cells leads to obesity in mice and affects neuronal differentiation in the hypothalamus early after birth

Conditional knockout of leptin receptor in neural stem cells leads to obesity in mice and affects neuronal differentiation in the hypothalamus early after birth

Abstract Leptin, secreted by peripheral adipocytes, binds the leptin receptor (Lepr) in the hypothalamus, thereby contributing to the regulation of satiety and body weight. Lepr is expressed in the embryonic brain as early as embryonic day 12.5. However, the function of Lepr in neural precursor cell...

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Bibliographic Details
Main Authors: Zhonggan Ren, Yitong Liu, Wentong Hong, Xinjie Pan, Pifang Gong, Qiong Liu, Guomin Zhou, Song Qin
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Molecular Brain
Subjects:
Hypothalamus
Leptin receptor
Arcuate nucleus
Neural stem cells
Neuronal differentiation
Online Access:http://link.springer.com/article/10.1186/s13041-020-00647-9

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http://link.springer.com/article/10.1186/s13041-020-00647-9

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